Dose-Response Modeling with Summary Data from Developmental Toxicity Studies
نویسندگان
چکیده
منابع مشابه
Summary of dose-response modeling for developmental toxicity studies.
Developmental toxicity studies are an important area in the field of toxicology. Endpoints measured on fetuses include weight and indicators of death and malformation. Binary indicator measures are typically summed over the litter and a discrete distribution is assumed to model the number of adversely affected fetuses. Additionally, there is noticeable variation in the litter responses within d...
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Over the past decades, pharmaceutical companies have conducted a large number of high-quality in vivo repeat-dose toxicity (RDT) studies for regulatory purposes. As part of the eTOX project, a high number of these studies have been compiled and integrated into a database. This valuable resource can be queried directly, but it can be further exploited to build predictive models. As the studies w...
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The Rai and Van Ryzin dose-response model proposed for teratology experiments has been characterized for its appropriateness and applicability in modeling the dichotomous response data from developmental toxicity studies. Modifications were made in the initial probability statements to reflect more accurately biological events underlying developmental toxicity. Data sets used for the evaluation...
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We develop a Bayesian nonparametric mixture modeling framework for replicated count responses in dose-response settings. We explore this methodology for modeling and risk assessment in developmental toxicity studies, where the primary objective is to determine the relationship between the level of exposure to a toxic chemical and the probability of a physiological or biochemical response, or de...
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About 25 years ago, McCullagh proposed a method for modeling univariate ordinal responses. After publishing this paper, other statisticians gradually extended his method, such that we are now able to use more complicated but efficient methods to analyze correlated multivariate ordinal data, and model the relationship between these responses and host of covariates. In this paper, we aim to...
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ژورنال
عنوان ژورنال: Risk Analysis
سال: 2016
ISSN: 0272-4332
DOI: 10.1111/risa.12667